Analysis of CD8+ T cells from primary human head and neck squamous cell carcinomas, regional LNs and blood shows that the non-metastatic TDLNs are the source of pre-exhausted CD8+ T cells (Tpex), which migrate to the tumor (52)
The glycocalyx and its significance in human medicine
Comparison across biofluids further highlighted both opportunity and constraint: while lumbar and ventricular CSF showed strong concordance, plasma profiles diverged substantially, particularly for immune-active pathways such as kynurenine metabolism 67 , indicating that treatment-relevant metabolic states are most directly captured in CSF and only partially reflected in peripheral blood
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The total radioactivity concentrations in the intestine, skin, and lungs were similar to those in the plasma, and the mean concentrations in the gonads, myocardium, skeletal muscle, brain, and body fat were all lower than the mean concentrations in the plasma
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