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The intestinal mucosa forms a critical interface between these microbes and the host: a single-cell epithelial layer with tight junctions that limit bacterial translocation, overlain by mucus and patrolled by immune cells [18]

Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: Results from two randomized, double-blind, placebo-controlled studies with single oral doses

This is consistent with the threshold concept described by World Health Organization [105]

Although GLP-1RAs are generally well tolerated and considered safe drugs, as they gain widespread use for obesity, rare but serious adverse effects such as gastroparesis, bowel obstruction, pancreatitis and non-arteritic anterior ischemic optic neuropathy are emerging

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However, the bone erosion was significantly inhibited after treatment with HA-RM-Cel-BR, with only negligible surface erosion