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The concentration of reactive oxygen species (ROS) in the ileum is modulated by bacterial load and can inhibit bacterial reflux from the distal intestine through inducible NOS and NADPH oxidase 1, resulting in the production of nitric oxide and superoxide radicals 94

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470 The drug is currently undergoing three clinical trials

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[DOI] [PubMed] [Google Scholar] Katakura K, Kishida K, Hirano H

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