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Second crystallographic fragment screen using the P4 1 2 1 2 TRF1 TRFH crystal system The results presented in Table 2 demonstrated the tractability of the NMR hit series and the possibility of obtaining more potent tool compounds through structure-guided optimisation

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The virus-induced hypoxia/Warburg effect could potentially compromise endocrinal, cardiovascular, neurocognitive, gastrointestinal, pulmonary, and reproductive functions that demand high levels of mitochondrial O 2 consumption, OXPHOS, and ATP reserve

Chondrocyte characteristics: Cartilage cells (chondrocytes) embedded in extensive extracellular matrix they produce and maintain

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