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Strength training and enough protein protect lean muscle mass, according to the American Diabetes Association, and losing that muscle (sometimes called sarcopenia) is a real risk with GLP-1 medications

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A hallmark effect of TZD treatment is the expansion of small, insulin-sensitive adipocytes, as reported in several studies [74,75]

Some anti-diabetic drugs can interfere with intracellular metabolic regulation, for example, through activation of AMPK or inhibition of glucose uptake, favoring TC cell death and also reducing its aggressiveness

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The review further highlights emergent research on "next-generation" therapies with weight-loss efficacy of up to about 24% in clinical trials, approaching weight-loss magnitudes reported in some surgical interventions