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Eumelanin production may be moderately reduced, which can translate into somewhat increased UV sensitivity and a moderate risk of photoaging over time

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Cagrilintide is engineered around that problem: it is a modified, lipidated peptide that acts as a dual amylin and calcitonin receptor agonist and is stable enough for once-weekly subcutaneous dosing

It works by inhibiting PCSK9 (proprotein convertase subtilisin/kexin type 9), allowing the liver to remove more LDL (bad) cholesterol from the blood

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