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L-Carnitine homeostasis reflects the balance among intestinal absorption, biosynthesis in several tissues, including the liver, kidney, and brain, renal reabsorption, and muscular storage ( Our previous study demonstrated that a 14-day daily administration of lenvatinib to rats reduced OCTN2 protein levels in the skeletal muscle and intestine, but not in the kidney, and consequently decreased L-carnitine content in the skeletal muscle ( in vitro

Uptake in skeletal and cardiac muscle is a saturable active transport process against a concentration gradient [16]

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