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Sorbitol, osmoregulation, and the complications of diabetes

A previous placebo-controlled study comparing orally administered tablets of phenylephrine or pseudoephedrine vs placebo support the conclusion that pseudoephedrine tablets are effective in reducing nasal congestion , whereas the effect produced by phenylephrine tablets are no different than placebo (Horak et al, 2009)

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These effects ultimately result in membrane destabilization, enzymatic inhibition, and dysfunction of signal transduction networks, causing metabolic imbalances that determine the threshold between adaptation and cell death

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