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TNF and IL-1 are capable of activating ERK and inducing the expression of IL-8 and IL-6 (41)

We confront a formidable challenge characterized by a surging number of high-risk patients, a growing prevalence of refractory microorganisms, and a sluggish pace in the development of novel drugs

Studies in diabetic animal models show that antioxidant treatment with N-acetyl cysteine and -tocopherol dramatically reduces oxidative stress, increases antibiotic sensitivity of biofilms, and promotes proper collagen deposition and remodeling

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Here, IL-6 secretion was driven not by CAFs, but rather by autophagy-inhibited PDAC cells