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In contrast with the modernity of CVD metabolomics, much of the translatable basic research is age-old and based in specific animal models

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Sadick and Harth 2016 in Journal of Cosmetic and Laser Therapy (18(8):422-427, PMID 27351303, 47 enrolled, 45 completed) documented statistically significant improvements in marionette lines, jawline lift, and facial lift, plus skin firmness, elasticity, texture, and dermal collagen content with 12 weeks of multisource home RF treatment using the NEWA 3DEEP device

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The animal study results are promising enough that it has become one of the most widely self-administered research peptides, but the absence of human trial data means all dosing is extrapolated from animal models adjusted for body weight.