However, it is unclear which of these, the size increase or HSA binding, are more pharmacologically relevant and account for the observed extension of the half-life.47 Another approach is PEGylating which may destroy the activity in vitro but retain the efficacy in vivo.15 Human serum albumin (HSA) and IgG have plasma half-lives of around 21 days, owing to HSA and the Fc domain of IgG interacting with the neonatal Fc receptor expressed in blood vessel endothelial cells, which rescues the proteins in the endosomes after pinocytosis, preventing them from entering the lysosomal pathway for destruction
Users stepping into this range should establish tolerance gradually
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Abramovitch, A., McKay, D., Milad, M
If you reconstitute Melanotan-2 with sterile water and then draw multiple doses from the same vial over days or weeks, you're introducing exponentially increasing bacterial loads with each needle puncture
