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F., Colovic, M., Yang, H

Schafer and Buettner (Free Radical Biology and Medicine, 2001) formalised the GSSG/2GSH couple as a quantitative index of the cellular redox environment, a framework still used to describe redox state across proliferation, differentiation and apoptosis in cultured cells

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Sitagliptin is also a substrate of P-glycoprotein (P-gp), which may also be involved in mediating the renal elimination of sitagliptin

Enhanced absorption likely reflects reduced molecular weight, resistance to peptidase cleavage, and improved paracellular diffusion