Obes Sci Pract
This sodium-independent antiporter is composed of two subunits: xCT (gene name SLC7A11 ), a subunit responsible for the amino acid exchange, and a chaperone CD98 (gene name SLC3A2 )
This is sometimes referred to as a methyl trap, where folate becomes functionally unavailable without sufficient B12, and vice versa
Stress is what lies at the core of this syndrome, so it is absolutely critical to manage it
Opioids inhibit NOS (Kampa et al., 2001), and this inhibition may need to be well-correlated with other effects of opioids (perhaps at NMDA coincidence detectors?) in order for the plasticity required for tolerance to occur
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