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Age 65 or Greater: The risk of metformin-associated lactic acidosis increases with the patient's age because elderly patients have a greater likelihood of having hepatic, renal, or cardiac impairment than younger patients

doi: 10.3390/ijms18010120 30 LiDDingZDuKYeXChengS

Animal trials testing injecting GLP-1 drugs into arthritic joints have also been undertaken

Not catastrophic, but worth knowing, especially if your last dose from a vial seems to come up short

Epidemiology of adult rheumatoid arthritis

Consequently, under the influence of synovial cytokines, particularly IL-1 and 17A, and reactive nitrogen intermediates, the cartilage is progressively deprived of chondrocytes that undergo apoptosis