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152,153 It is worth mentioning that a major activator of TSC1/2 signalling is BDNF, a secreted protein that binds to the receptor tyrosine factor TrKB and is thereby involved in the PI3K/mTOR pathway

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There are disputes over how concerning this should be as a side effect, but some studies show as much as 40 to 60 percent of the total weight loss on GLP-1 drugs comes from lean muscle mass

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