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Emerging evidence indicates that dependence can be shaped by metastatic niche, antioxidant nutrient availability and tumor genotype (for example, NRF2/KEAP1 signaling, baseline GPX4 expression and lipid composition)

2019;4:e126742

All electron microscopy was performed at the Multi-User CryoEM Facility at the Centre for Structural Systems Biology, Hamburg, supported by the University of Hamburg and DFG grant numbers INST 152/772-1|152/774-1|152/776-1 FUGG

doi: 10.1016/j.molmet.2021.101206 107 ColletTHDubernBMokrosinskiJConnorsHKeoghJMMendes, de OliveiraEet al

These studies further revealed that GSH depletion specifically impacted mitochondrial genome stability rather than nuclear genome stability, highlighting the essential requirement for GSH in mitochondrial metabolism