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A realistic projected pathway often looks like: Regulatory submissions: potentially 20262027 (depending on Phase 3 completion and dossier readiness) Possible first approvals: potentially 20272028 (jurisdiction dependent) UK MHRA decision window: may follow after submission and review (timing varies) NICE appraisal (for NHS access): often occurs after MHRA approval and can add additional time Important note: even after MHRA approval, NHS availability can take longer due to NICE assessment and commissioning pathways

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