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Common side effects include gastrointestinal issues such as nausea, vomiting, and diarrhea

While there is one oral version of semaglutide currently available on the market, its results have been inferior to the injectable alternatives

For patients with polypharmacy, comorbid endocrine disease, or family history of thyroid malignancy, in-depth clinical evaluation is essential before GLP-1 initiation

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Combining treatments can sometimes enhance results, but it can also increase the risk of side effects

The main findings deduced by the results in this study are as follow: (1) GLP-1 increases RSNA to regulate diuresis and natriuresis in an inhibitory manner, in which the afferent renal nerve activation is potentiated via elevated GLP-1R expression in the renal pelvis of rats with HF