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Pharmacodynamic principles can be used to predict the concentration required to achieve a particular degree of therapeutic effect

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To tighten barrier integrity and induce BBB properties, a cocktail of small molecules, cARLA, was applied to activate the cyclic AMP and Wnt/-catenin and inhibit the TGF- signaling pathways (Fig

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In preclinical studies, Elamipretide has shown promise in mitigating tissue damage following ischemia-reperfusion injury, preserving cardiac function after myocardial infarction, and ameliorating neurodegenerative processes (Birk et al., 2017