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Often yes, and they can be complementary because they do different jobs

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doi:10.1016/j.ejphar.2015.09.024 87

Rheumatologists often adjust allopurinol doses higher than 300mg when needed to reach uric acid goal, although the literature on higher doses of allopurinol is limited

In addition, there is considerable evidence that estrogen increases substantially the activities of GPX and Glutamate Cysteine Ligase (GCL), an enzyme in the GSH pathway [5-7]