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To put it in context, for somebody whose ideal healthy bodyweight is 170 but is starting out at 260, they would, in theory, get down to 221 on semaglutide, 208 on tirzepatide, and 197 on retatrutide, a faster pace of weight loss

They found 496 deaths in the AS cohort and 1533 deaths in the controls resulting in an age-adjusted and sex-adjusted HR of 1.60 (95% CI 1.44 -1.77)

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patients should refer to their prescriber or the MHRA/EMC SmPC for specific licensed cardiovascular indications