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However, because human clinical data is limited, a comprehensive understanding of potential side effects in humans is not yet established

ACTH is derived from cleavage of the precursor hormone pro-opiomelanocortin (POMC) by prohormone convertase enzymes

doi: 10.1136/bmjopen-2020-041393

Advanced glycation endproducts, dityrosine and arginine transporter dysfunction in autisma source of biomarkers for clinical diagnosis

As the oxidative burden on the nervous system decreases, the autonomic nervous system can begin to shift back toward parasympathetic dominance (the "rest-and-digest" state)

Furthermore, the gut microbiome is associated with changes in brain structure and function in SZ patients, as evidenced by neuroimaging studies linking microbial -diversity to alterations in gray matter volume and regional homogeneity (75)