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10.1136/gut.2003.035279 102

Additionally, several systematic reviews have indicated that semaglutide is primarily associated with an increased risk of cholelithiasis (Smits and Van Raalte, 2021

2021 May 18;41(6):NP521NP537.

This step might involve acid-base catalysis by the active-site cysteinyl thiolate (which could explain an effect of the second cysteinyl residue), and/or the conserved lysine residue, yielding GS in analogy to glutathione transferases (Fig

"It's the first new drug for function and symptoms in PAD in 25 years, after many attempts to find novel therapies," says study leader Dr