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1999 Aug;12(2):139-57

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PEGylation the covalent attachment of polyethylene glycol (PEG) chains via a succinyl linker surrounds the peptide with a steric hydrophilic shield that dramatically increases hydrodynamic radius, reduces renal filtration, and provides protection from proteolytic degradation

These two hormones play a crucial role in cell growth, repair, metabolism, and recovery

When scientists looked at standard, naturally occurring IGF-1, they noticed a massive roadblock: as soon as it enters the bloodstream, the body binds it up using IGF Binding Proteins (specifically IGFBP-3)

Beyond the primary endpoint, the trial revealed a 22 percent reduction in a composite kidney endpoint, suggesting renal protective effects