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In SUSTAIN-6, patients on semaglutide experienced an average 4 mmHg greater systolic drop than placebo after 30 weeks, independent of weight loss (see the SUSTAIN-6 trial publication )
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The anti-inflammatory effects of short chain fatty acids on lipopolysaccharide- or tumor necrosis factor -stimulated endothelial cells via activation of GPR41/43 and inhibition of HDACs
Oral GLP-1 agents have been widely studied, with high-dose oral semaglutide currently under investigation for cardiovascular risk reduction but not yet established as reducing major adverse cardiovascular events
