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Both sublingual and nasal spray delivery bypass first-pass metabolism and provide faster onset than oral capsules

The fact that the double-cysteine mutations only partially abolish the physiological function may imply that not all the expressed mutants have an intact disulfide bridge and that the observed conformation is only one possible inactive state on the cell surface, as supported by the EM data and MD simulations below

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Currently, it is documented that the major redox control for these enzymes is a feedback inhibition exerted by GSH on GCL (Meyer and Fricker, 2002)

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