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A serious systemic disturbance called metabolic acidosis can occur in CKD when acidic compounds, especially nitrogen-containing waste from dietary protein metabolism, accumulate in the blood

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For example, glutamate to be used as a neurotransmitter is compartmentalized from metabolic glutamate used for protein synthesis by packaging the transmitter into synaptic vesicles for subsequent Ca 2+ -dependent release

Grading of dysplasia in Barretts oesophagus: substantial interobserver variation between general and gastrointestinal pathologists

Bieniek, J