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These effects are further compounded by immune dysregulation: hypoxia-induced proinflammatory cytokines [e.g., Interleukin (IL)-6, tumor necrosis factor (TNF)-] disrupt the T helper cell 17/Regulatory T cells balance, aggravating endothelial damage and vascular leakage in HAPE (Ulloa and Cook, 2025)

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Summary Successful treatment of obesity requires a multidisciplinary approach and multimodal therapy including dietary and behavioral strategies