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Because some of the same brain and body systems that regulate appetite also influence reward and craving, researchers are now asking whether these medications could also help people reduce alcohol and other substance use

For example, the SELECT trial showed a 20% improvement in major cardiovascular events (i.e., heart attacks, strokes, and deaths from those cases) in adults on weekly semaglutide who were overweight or obese (without diabetes) and with preexisting cardiovascular disease, as well as an improvement in all-cause mortality of 19%

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Stopping GLP-1 treatment is not a failure

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Those pages separate the archive by research intent, while this article separates the two melanocortin options by receptor biology