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Additionally, stress-inducing agents such as tunicamycin, thapsigargin and histidinol have been shown to modulate CHAC1 regulation, indicating its involvement not only during ER stress but also in the context of the ISR ( CHAC1 promoter is the primary mechanism for the transcriptional upregulation of the gene

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doi: 10.1002/pmic.201800419

doi: 10.1016/j.pharmthera.2020.107538 101 PavanICBBaseiFLSeverinoMBSilvaIREIssayamaLKManciniMCSet al

In another aspect of Project 2, we showed that the answer to this question is No

A: Store each vial in a cool, dry place away from light and moisture, keeping it within the recommended shelf life of 24 months from the manufacture date