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(Montreal, Canada) and first described in peer-reviewed literature in the context of dipeptidylpeptidase-4 (DPP-4) resistance: native GHRH is rapidly cleaved in circulation by DPP-4 at the TyrAla bond, and the N-terminal hexenoyl modification was structurally characterized as blocking this cleavage site, preserving the intact GHRH(144) sequence for hypothalamic-pituitary receptor interaction in preclinical models

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10.1016/s0140-6736(17)31046-31042 Lancet 33 FasoloA.SessaC.GianniL.BrogginiM

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