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Front Endocrinol (Lausanne) (2023) 14:1139444

The Bencao Gangmu (1596 CE) mentioned that Chuanxiong and Danggui were used in ancient times to treat headaches (19)

In subchondral bone, chronic mechanical stress leads to microfracture, osteosclerosis, and angiogenesis, often accompanied by excessive iron deposition and oxidative stress

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Notably, a recent study published by the Washington State Department of Ecology analyzed data for 2016 to 2020 and found that residents of sixteen counties in the state that were overburdened with wildfire smoke faced a higher death rate from air pollution than the state average