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Antibodies used: p53 (32532 (D2H9O), 1:1000 Cell Signalling, Danvers, MA, United States), human p53 (sc-126 (DO-1), 1:3000, Santa Cruz Biotechnology, Dallas, Texas, United States), GAPDH (2118 (14C10), 1:5000, Cell Signalling, Danvers, MA, United States), -actin (Ab6276 (AC-15), 1:250,000, Abcam, Cambridge, United Kingdom), vinculin (PA5-29688, 1:1000, Thermo Fisher Scientific, Waltham, MA, United States), MMP12 (ab52897 (EP1261Y), 1:1000, Abcam, Cambridge, United Kingdom)

[DOI] [PMC free article] [PubMed] [Google Scholar] Yamamoto S, Ohta N, Matsumoto A, Horiguchi Y, Koide M, Fujino Y (2016) Haloperidol suppresses NF-kappaB to inhibit lipopolysaccharide-induced pro-inflammatory response in RAW 264 cells

4C), indicating metabolic disturbances in the Model group

TB-500 is the synthetic version of a short fragment of Thymosin Beta-4 , a naturally occurring 43-amino-acid peptide

Recently, vinca alkaloids have demonstrated to exert their neurotoxicity via activation of spinal cord glia (i.e., astrocytes and microglia), offering an option for the treatment of CIPN through pharmacological antagonism of this phenomenon