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The mechanism may be related to the decrease of forkhead-box class O (FOXO) transcription factor expression in chondrocytes, thus weakening the cell's resistance to oxidative stress [41]

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Higher concentrations (10mg/mL or greater) reduce injection volume but amplify measurement erroreach 0.01mL syringe increment represents 100mcg peptide, introducing 2040% relative error for sub-250mcg doses

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however, for most thiolates including that formed by glutathione, the rate of the non-enzymatic reaction is too slow to account for the inactivation of the enzymes (Forman, 2007)

It does not show any structural similarity with fumagillin, nor does it covalently bind the target protein or require parenteral application