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The docking analyses revealed that the positioning of the GSH-thiolate in relation to C-2 and O-3 of the docked substrates could enable an acidbase mechanism of dehydration or tautomerization, in which the GSH cofactor acts as a proton-relay system (Fig

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Lee PA, Nordenstrom A, Houk CP, Ahmed SF, Auchus R, Baratz A, Baratz Dalke K, Liao LM, Lin-Su K, Looijenga LH 3rd, et al

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