B12 supplementation has been reported to help with fatigue and nausea that semaglutide users commonly experience, though the evidence for this is largely anecdotal rather than clinical
Nauck MA, Quast DR, Wefers J, Meier JJ (2021) GLP-1 receptor agonists in the treatment of type 2 diabetes state-of-the-art
For example, one extensive review of semaglutides safety discusses the incidence of pancreatitis in study participants, as well as the potential link between GLP-1 RAs and pancreatic cancer.16 Its a sensible thing to study considering these drugs effect on the pancreas, and cases of pancreatitis were present in several studies, but researchers note that the incidence isnt meaningfully higher than that of the general population outside the study group
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However, it isnt regulated as closely as drugs approved by the FDA
Xenical and Alli (orlistat) While both are oral weight loss medications, Xenical is a prescription drug, and Alli is available over-the-counter (OTC)