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As a long-acting analog of human IGF-1, it is engineered to deliver more substantial and more sustained receptor activity, driving muscle growth, tissue regeneration, and metabolic enhancement

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However, binding to the GLP-1 receptor also seems significant in tirzepatides cell surface receptor mechanism, as tirzepatide had no effect on body weight, food intake, fasting insulin levels, skeletal muscle, subcutaneous adipose tissue endogenous glucose production, or insulin-stimulated glucose uptake in GLP-1 receptor non-expressing knockout mice [93]

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