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These include ER stress signaling, the integrated stress response (ISR) and reactive oxygen species (ROS)-mediated apoptosis

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While it is perhaps somewhat surprising that no group differences in metabolite concentrations were found, either for GABA (as has been shown before) or for GSH, we note that autism is an extremely heterogeneous condition, and that group differences, if present, may be small and relatively uninformative in understanding the broader autism phenotype(Loth et al., 2021)

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Therefore, various APAP doses were tested to assess susceptibility to APAP-induced toxicity, aiming to investigate potential differences in tolerance between wild-type and hepsin / mice