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Remodeling phase exhibits improved collagen organization and reduced fibrosis, resulting in stronger, more functional repaired tissue with minimal scarring

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505,506,507 ARIs Epalrestat is an aldose reductase inhibitor that prevents the accumulation of sorbitol and fructose within nerve cells, which can cause osmotic stress and neuronal damage

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Critical limb ischemia (CLI) is a kind of PVD with a high incidence rate, caused by tissue ischemia and hypoxia after arterial stenosis or occlusion