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When incubated with either GLP-1 WT, GLP-1 QMP, or Exendin-4, the pancreatic islet cells isolated from the WT mice secreted similar amounts of insulin, 3 to 4.5-fold more than when incubated with unfused WT albumin (Fig

Specifically, sulfasalazine, an XCT inhibitor, appears useful in the treatment of pancreatic and small-cell lung cancer cells 69,70 , while NOV-002, a glutathione disulfide mimetic that alters the GSSG/GSH ratio and induces oxidative stress, has been favorably used in patients with HER2-negative breast cancer 71

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These core characteristics are systematically compared in Table 4