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Long-Term Medication Users Medications such as metformin (used for diabetes) and proton pump inhibitors (used for acid reflux) can interfere with B12 absorption when taken long term, making supplementation necessary

MRI and dual-energy X-ray absorptiometry (DEXA) scans confirmed marked reductions in white adipose tissue throughout the body

Phase 2 (Jastreboff 2023) cutaneous category 12.9% at 12 mg vs 1.4% placebo

Vague claims of "feeling younger" are indistinguishable from a placebo

doi:10.1002/14651858.CD001043

Many experienced users employ a combination approach, using local injection near the primary injury 4 to 5 days per week with occasional systemic injection for comprehensive healing support