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At 68 weeks, CagriSema produced a mean body weight reduction of 22.7% from baseline

Skin Biopsy Skin biopsies were obtained at baseline and after 28 d from the proximal thigh (20 cm below the anterior superior iliac spine) and the distal leg (10 cm above the lateral malleolus) by using a disposable punch biopsy (3 mm) and processed following established guidelines (25)

Most patients begin noticing shifts in symptoms reduced flare frequency, less urgency, improved tolerance within 48 weeks, with continued improvement over 36 months

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