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doi: 10.3389/fcvm.2024.1446468 Received 09 June 2024 Accepted 21 November 2024 Published 16 December 2024 Volume 11 - 2024 Edited by Masanori Aikawa, Brigham and Women's Hospital and Harvard Medical School, United States Reviewed by Prabhash Kumar Jha, Brigham and Women's Hospital and Harvard Medical School, United States Satyesh K

Beyond cancer, PRODH dysfunction is also linked to neuropsychiatric and metabolic diseases, including schizophrenia 65,66 , and hyperprolinemia type I 67 , reflecting its broader role in regulating mitochondrial redox balance and prolineglutamate neurotransmitter metabolism

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