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In one study, the clearance of free valproate was decreased by 50% in 7 patients with cirrhosis and by 16% in 4 patients with acute hepatitis, compared with 6 healthy subjects

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With GLP-1s still relatively new on the scene for their weight loss indication, were only just beginning to see published data on medication persistence rates, and very little in the peer-reviewed literature

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Both produce therapeutic CNS concentrations, but subcutaneous allows for longer intervals between observable plasma peaks, which may reduce variability in studies measuring acute cognitive effects

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