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Timing is flexible and less important than being consistent

One compelling histopathological correlate of disability progression is the slowly-expanding lesion, characterized by a presumably inactive gliotic demyelinated center surrounded by a rim of activated microglia and macrophages containing degenerated myelin, injured axons and often iron deposition (Dal-Bianco et al., 2017

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The observation of metal sulphides as neutral fragments in the unimolecular decomposition of bio-organic ions is relatively rare, and only one case has been very recently reported in a study of lead-binding metallothionein [122] (see below)

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34 (7), e201900708