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They should be monitored closely for both efficacy and adverse effects, with clear instructions to report any unusual symptoms

Both insulin and IGF-1 are growth-stimulating and anabolic hormones, and insulin and IGF receptor activation upregulates pathways central to carcinogenesis (see Figure 2)

Side Effects and Considerations Like all medications, semaglutide can cause side effects

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Per the UK SmPC/PIL, approved sites for GLP-1 receptor agonists are the abdomen, thigh, and upper arm

People taking other medications Both tirzepatide and semaglutide slow gastric emptying, which can affect absorption of oral medications