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XN protects mice from DSS-induced colitis and H 2 O 2 - or LPS-treated IEC-6 injury, possibly by the interaction between the , -unsaturated carbonyl moiety of XN and Cys99 in IKK, and thus by its ability to inhibit the IKK/NF-B signaling pathway

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Park JH, Yoon YK, Choi SO, Prausnitz MR, Allen MG

Collectively, these preliminary findings support the effectiveness of daily liposomal GSH administration at elevating stores of GSH and impacting immune function and levels of oxidative stress.

Long-term safety studies (beyond 6 months) do not appear to have been conducted for oral glutathione [1]

J Cell Biochem 118(11):38253833