Side Effects Comparison# Retatrutide Side Effects# Phase 2 data (n=338 obesity trial): Nausea : ~25% at higher doses (8-12 mg) Diarrhea : ~20% Vomiting : ~15% Constipation : Common Decreased appetite : Common (pharmacological effect) Heart rate : Small increase (2-4 bpm), potentially related to glucagon component Injection site reactions : Mild, transient Discontinuation rate : 6-10% due to adverse events The glucagon receptor component introduces theoretical concerns for hyperglycemia (counterbalanced by GLP-1/GIP in practice), cardiovascular effects (chronotropic glucagon action), and hepatic effects, none of which produced safety signals in Phase 2 but require larger-scale monitoring
Prediction based on multi-omics data To date, omics data for ML algorithms of PCOS complications assessment in the existing literature are mainly gene and protein information obtained from clinical samples and biological information databases (the GEO and Gene Cards database), as well as biological components of follicular fluid analyzed by Raman spectra
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doi:10.1093/ajcn/80.6.1551 Funk RS, Jones J, Polireddy K, et al
This pattern is totally normal and typically improves with each adjustment
[72] [73] Instead, storylines are developed by a team of five "outline and premise" writers
