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These connections form the microbiota-gut-brain axis (MGBA)

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Different doses of leptin administration also improved glucose metabolism and thermoregulation in ob/ob mice (12)

Numerous studies have reported the anti-diabetic effects of tea polyphenols in experimental diabetes models, demonstrating their ability to lower blood glucose levels, improve insulin sensitivity, and reduce oxidative stress and inflammation associated with type 2 diabetes mellitus (377, 378)