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[78] that assessed the effects of SGLT2is in PCOS

The trial enrolled 120 adults and children as young as four, randomized 2:1 to once-daily subcutaneous setmelanotide or placebo, and ran for a full year, making it the largest and longest placebo-controlled study ever conducted in this patient population

Tracking symptom severity, distribution, and functional impact on a consistent schedule reveals trends that day-to-day subjective impressions would miss

Modulating the excitability of olfactory output neurons affects whole-body metabolism

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